Mifepristone is used in a regimen together with misoprostol to end a pregnancy that is less than 70 days in duration. It works by stopping the supply of hormones that maintains the interior of the uterus. Without these hormones, the uterus cannot support the pregnancy and the contents of the uterus are expelled.
Mifepristone is also used to control high blood sugar (hyperglycemia) caused by high cortisol levels in the blood (hypercortisolism) in patients with Cushing's syndrome who also have type 2 diabetes and have failed surgery or who cannot have surgery.
A combined mifepristone and misoprostol regimen is more effective than misoprostol used alone, and is recommended for medical abortion before 13 weeks; where mifepristone is unavailable, the misoprostol-only regimen can be used.
Additional doses of misoprostol can be used if bleeding, cramping, or pregnancy expulsion have not occurred, and at least 3 hours have passed since the previous misoprostol dose.
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