Qsymia is a prescription-only medication combining phentermine (an appetite suppressant) and topiramate (an anticonvulsant with satiety effects) in extended?release capsules. It’s FDA-approved for chronic weight management in adults (and certain adolescents aged ≥12) who are obese (BMI?≥?30) or overweight (BMI?≥?27) with coexisting weight-related health conditions like hypertension or type 2 diabetes
Clinical trials show 7–8% average weight reduction at 7.5?mg/46?mg and 10–11% at maximal dose compared to placebo after one year, when combined with diet and exercise
Associated benefits include lowered blood pressure, better glycemic control in type 2 diabetes, and improved lipid levels
Initial dose: 3.75?mg/23?mg once daily in the morning, with or without food, for 14 days.
Titrate upward: If tolerated, increase to 7.5?mg/46?mg once daily thereafter.
Evaluate after 12 weeks:
<3% weight loss → consider stopping or increasing to 11.25?mg/69?mg, then possibly 15?mg/92?mg daily.
≥5% weight loss at maximum dose → continue up to 56 weeks.
Monitor: Regular check-ups are required to assess weight, cardiovascular status, and side effects.
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